Acute and Critical Care

Editorial

CPR/Resuscitation
Extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest and in-hospital cardiac arrest with return of spontaneous circulation: be careful when comparing apples to oranges: Hwa Jin Cho, In Seok Jeong, Jan Bělohlávek; Acute Crit Care. 2023;38(2):242-243. Published online May 31, 2023; DOI: https://doi.org/10.4266/acc.2023.00731

818 View
52 Download

PDF

Review Articles

Basic science and research
Extracorporeal circulation models in small animals: beyond the limits of preclinical research: Mukhammad Kayumov, Reverien Habimana, Dowan Kim, Francis O Obiweluozor, In Seok Jeong, Hwa Jin Cho; Acute Crit Care. 2023;38(1):1-7. Published online February 28, 2023; DOI: https://doi.org/10.4266/acc.2023.00381

2,148 View
192 Download
2 Web of Science
3 Crossref

Extracorporeal membrane oxygenation (ECMO) use has remarkably increased in recent years. Although ECMO has become essential for patients with refractory cardiac and respiratory failure, extracorporeal circulation (ECC) is associated with significant complications. Small-animal models of ECC have been developed and widely used to better understand ECC-induced pathophysiology. This review article summarizes the development of small-animal ECC models, including the animal species, circuit configuration, priming, perioperative procedures, cannulation, and future perspectives of small-animal ECMO models.

Citations

Citations to this article as recorded by

Venoarterial Extracorporeal Membrane Oxygenation Implementation in Septic Shock Rat Model
Tianlong Wang, Mingru Zhang, Wenhao Dong, Jing Wang, Han Zhang, Yuefu Wang, Bingyang Ji
ASAIO Journal.2024;[Epub] CrossRef
Multiorgan recovery in a cadaver body using mild hypothermic ECMO treatment in a murine model
Nodir Madrahimov, Vitalii Mutsenko, Ruslan Natanov, Dejan Radaković, André Klapproth, Mohamed Hassan, Mathias Rosenfeldt, Florian Kleefeldt, Ivan Aleksic, Süleyman Ergün, Christoph Otto, Rainer G. Leyh, Constanze Bening
Intensive Care Medicine Experimental.2023;[Epub] CrossRef
Post-Mortem Extracorporeal Membrane Oxygenation Perfusion Rat Model: A Feasibility Study
Matthias Manfred Deininger, Carl-Friedrich Benner, Lasse Johannes Strudthoff, Steffen Leonhardt, Christian Simon Bruells, Gernot Marx, Christian Bleilevens, Thomas Breuer
Animals.2023; 13(22): 3532. CrossRef

Basic science and research
Sepsis-induced cardiac dysfunction: a review of pathophysiology: Reverien Habimana, Insu Choi, Hwa Jin Cho, Dowan Kim, Kyoseon Lee, Inseok Jeong; Acute Crit Care. 2020;35(2):57-66. Published online May 31, 2020; DOI: https://doi.org/10.4266/acc.2020.00248

13,487 View
906 Download
43 Web of Science
48 Crossref

Abstract PDF

It is well known that cardiac dysfunction in sepsis is associated with significantly increased mortality. The pathophysiology of sepsis-induced cardiac dysfunction can be summarized as involving impaired myocardial circulation, direct myocardial depression, and mitochondrial dysfunction. Impaired blood flow to the myocardium is associated with microvascular dysfunction, impaired endothelium, and ventriculo-arterial uncoupling. The mechanisms behind direct myocardial depression consist of downregulation of β-adrenoceptors and several myocardial suppressants (such as cytokine and nitric oxide). Recent research has highlighted that mitochondrial dysfunction, which results in energy depletion, is a major factor in sepsis-induced cardiac dysfunction. Therefore, the authors summarize the pathophysiological process of cardiac dysfunction in sepsis based on the results of recent studies.

Citations

Citations to this article as recorded by

Neonatal sepsis and cardiovascular dysfunction I: mechanisms and pathophysiology
Sophie M. Duignan, Satyan Lakshminrusimha, Kathryn Armstrong, Willem P. de Boode, Afif El-Khuffash, Orla Franklin, Eleanor J. Molloy, Willem P. de Boode, Franz B. Plötz, Tobias Strunk, Marina Degtyareva, Helmut Küster, Eric Giannoni, Joseph M. Bliss, H. R
Pediatric Research.2024; 95(5): 1207. CrossRef
6-Gingerol, an ingredient of Zingiber officinale, abrogates lipopolysaccharide-induced cardiomyocyte injury by reducing oxidative stress and inflammation
Azar Hosseini, Mohaddeseh Sadat Alavi, Mitra Ghane Nikookar Toos, Tannaz Jamialahmadi, Amirhossein Sahebkar
Journal of Agriculture and Food Research.2024; 15: 101034. CrossRef
Inflammation and arrhythmogenesis: a narrative review of the complex relationship
Andia Taghdiri
International Journal of Arrhythmia.2024;[Epub] CrossRef
Inotropic drugs in septic shock
Nutnicha Yolsiriwat, Surat Tongyoo
Clinical Critical Care.2024;[Epub] CrossRef
Epigallocatechin-3-gallate protects sepsis‐induced myocardial dysfunction by inhibiting the nuclear factor-κB signaling pathway
Bei Chen, Ya-Fei Li, Zhang Fang, Wen-Yi Cai, Zhi-Qiang Tian, Dianfu Li, Ze-Mu Wang
Heliyon.2024; 10(5): e27163. CrossRef
Myocardial Injury as a Harbinger of Multi-organ Failure in Septic Shock: A Comprehensive Review
Amol Singam
Cureus.2024;[Epub] CrossRef
Case 9-2024: An 84-Year-Old Man with a Fall
Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, Tara Corpuz, Zaven Sargsyan, Sunita D. Srivastava, Virginia A. Triant, Brian B. Ghoshhajra
New England Journal of Medicine.2024; 390(12): 1129. CrossRef
Melatonin: A potential protective multifaceted force for sepsis-induced cardiomyopathy
Eman Casper, Lamia El Wakeel, Nagwa Sabri, Ramy Khorshid, Sarah F. Fahmy
Life Sciences.2024; 346: 122611. CrossRef
Hemodynamic goals in sepsis and septic shock resuscitation: An umbrella review of systematic reviews and meta-analyses with trial sequential analysis
Daniele Orso, Nicola Federici, Cristina Lio, Filippo Mearelli, Tiziana Bove
Australian Critical Care.2024;[Epub] CrossRef
A case of sepsis‐induced cardiomyopathy successfully treated with venoarterial extracorporeal membrane oxygenation
Keigo Sato, Akihiro Naito, Taichi Shiratori, Masahiro Yamamoto, Kenichi Shimane, Manabu Mikami, Mariko Senda, Haruki Kume, Motofumi Suzuki
IJU Case Reports.2023; 6(1): 26. CrossRef
Jujuboside A attenuates sepsis-induced cardiomyopathy by inhibiting inflammation and regulating autophagy
Zi Wang, Danrui Xiao, Qingqi Ji, Yanjie Li, Zhaohua Cai, Liang Fang, Huanhuan Huo, Guo Zhou, Xiangming Yan, Linghong Shen, Ben He
European Journal of Pharmacology.2023; 947: 175451. CrossRef
Mitochondrial transplantation protects against sepsis-induced myocardial dysfunction by modulating mitochondrial biogenesis and fission/fusion and inflammatory response
Behnaz Mokhtari, Masoud Hamidi, Reza Badalzadeh, Ata Mahmoodpoor
Molecular Biology Reports.2023; 50(3): 2147. CrossRef
Therapeutic potentials of stem cell–derived exosomes in cardiovascular diseases
Saiprahalad Mani, Narasimman Gurusamy, Thennavan Ulaganathan, Autumn J Paluck, Satish Ramalingam, Johnson Rajasingh
Experimental Biology and Medicine.2023; 248(5): 434. CrossRef
CLINICAL, MOLECULAR, AND EXOSOMAL MECHANISMS OF CARDIAC AND BRAIN DYSFUNCTION IN SEPSIS
Daniel C. Morris, Zheng Gang Zhang, Anja K. Jaehne, Jing Zhang, Emanuel P. Rivers
Shock.2023; 59(2): 173. CrossRef
Circulating protein and lipid markers of early sepsis diagnosis and prognosis: a scoping review
Gemma Barber, Jelena Tanic, Aleksandra Leligdowicz
Current Opinion in Lipidology.2023; 34(2): 70. CrossRef
Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis
Simon T. Abrams, Yasir Alhamdi, Min Zi, Fengmei Guo, Min Du, Guozheng Wang, Elizabeth J. Cartwright, Cheng-Hock Toh
International Journal of Molecular Sciences.2023; 24(4): 3225. CrossRef
Septic cardiomyopathy: A narrative review
Maria Rita Lima, Doroteia Silva
Revista Portuguesa de Cardiologia.2023; 42(5): 471. CrossRef
Enfoque de la miocardiopatía séptica como causa de choque refractario en escenarios de recursos limitados: reporte de caso
Liliana Correa-Pérez, Diana Carolina Otálora Álvarez, Gloria Camila Álvarez Gallego
Acta Colombiana de Cuidado Intensivo.2023; 23(3): 303. CrossRef
Role of Pellino-1 in Inflammation and Cardioprotection following Severe Sepsis: A Novel Mechanism in a Murine Severe Sepsis Model †
Mahesh Thirunavukkarasu, Santosh Swaminathan, Andrew Kemerley, Seetur R. Pradeep, Sue Ting Lim, Diego Accorsi, Rickesha Wilson, Jacob Campbell, Ibnalwalid Saad, Siu-Pok Yee, J. Alexander Palesty, David W. McFadden, Nilanjana Maulik
Cells.2023; 12(11): 1527. CrossRef
circHIPK3 exacerbates sepsis-induced acute kidney injury and cardiopulmonary function by regulating microRNA-106a-5p/ROCK2 axis
Heng Li, Lingkai Kang, Jianglu Tan, Wanli Li, Dongrui He, Jing Han, Jie Zhang, Yulin Guan, Ying Huang, Xiaoyue Li
Process Biochemistry.2023; 131: 272. CrossRef
Estradiol as the Trigger of Sirtuin-1-Dependent Cell Signaling with a Potential Utility in Anti-Aging Therapies
Kamil Karolczak, Cezary Watala
International Journal of Molecular Sciences.2023; 24(18): 13753. CrossRef
Baricitinib protects mice from sepsis-induced cardiac dysfunction and multiple-organ failure
Chiara Verra, Shireen Mohammad, Gustavo Ferreira Alves, Elisa Porchietto, Sina Maren Coldewey, Massimo Collino, Christoph Thiemermann
Frontiers in Immunology.2023;[Epub] CrossRef
Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction
Gabriel Jakobsson, Praveen Papareddy, Henrik Andersson, Megan Mulholland, Ravi Bhongir, Irena Ljungcrantz, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Adrian Manea, Heiko Herwald, Marisol Ruiz-Meana, Antonio Rodríguez-Sinovas, Michelle Chew, Alexa
Critical Care.2023;[Epub] CrossRef
Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis
Peiqiu Zheng, Xing Wang, Tao Guo, Wei Gao, Qiang Huang, Jie Yang, Hui Gao, Qian Liu
Immunity, Inflammation and Disease.2023;[Epub] CrossRef
Decoding molecular signature on heart of septic mice with distinct left ventricular ejection fraction
Lina Zhang, Desheng Qi, Milin Peng, Binbin Meng, Xinrun Wang, Xiaolei Zhang, Zhihong Zuo, Li Li, Zhanwen Wang, Wenxuan Zou, Zhonghua Hu, Zhaoxin Qian
iScience.2023; 26(10): 107825. CrossRef
Role of toll-like receptor-mediated pyroptosis in sepsis-induced cardiomyopathy
Yixuan Fan, Baoyi Guan, Jianxing Xu, He Zhang, Liang Yi, Zhixu Yang
Biomedicine & Pharmacotherapy.2023; 167: 115493. CrossRef
Understanding yellow fever-associated myocardial injury: an autopsy study
Fernando Rabioglio Giugni, Vera Demarchi Aiello, Caroline Silverio Faria, Shahab Zaki Pour, Marielton dos Passos Cunha, Melina Valdo Giugni, Henrique Trombini Pinesi, Felipe Lourenço Ledesma, Carolina Esteves Morais, Yeh-Li Ho, Jaques Sztajnbok, Sandra de
eBioMedicine.2023; 96: 104810. CrossRef
The role of beta-blocker drugs in critically ill patients: a SIAARTI expert consensus statement
Fabio Guarracino, Andrea Cortegiani, Massimo Antonelli, Astrid Behr, Giandomenico Biancofiore, Alfredo Del Gaudio, Francesco Forfori, Nicola Galdieri, Giacomo Grasselli, Gianluca Paternoster, Monica Rocco, Stefano Romagnoli, Salvatore Sardo, Sascha Treska
Journal of Anesthesia, Analgesia and Critical Care.2023;[Epub] CrossRef
Sedation for Patients with Sepsis: Towards a Personalised Approach
José Miguel Marcos-Vidal, Rafael González, María Merino, Eva Higuera, Cristina García
Journal of Personalized Medicine.2023; 13(12): 1641. CrossRef
High serum nitrates levels in non-survivor COVID-19 patients
L. Lorente, F. Gómez-Bernal, M.M. Martín, J.A. Navarro-Gonzálvez, M. Argueso, A. Perez, L. Ramos-Gómez, J. Solé-Violán, J.A. Marcos y Ramos, N. Ojeda, A. Jiménez
Medicina Intensiva.2022; 46(3): 132. CrossRef
Vital signs as physiomarkers of neonatal sepsis
Brynne A. Sullivan, Karen D. Fairchild
Pediatric Research.2022; 91(2): 273. CrossRef
Fluid therapy for severe malaria
Laura C Kalkman, Thomas Hänscheid, Sanjeev Krishna, Martin P Grobusch
The Lancet Infectious Diseases.2022; 22(6): e160. CrossRef
High serum nitrates levels in non-survivor COVID-19 patients
L. Lorente, F. Gómez-Bernal, M.M. Martín, J.A. Navarro-Gonzálvez, M. Argueso, A. Perez, L. Ramos-Gómez, J. Solé-Violán, J.A. Marcos y Ramos, N. Ojeda, A. Jiménez
Medicina Intensiva (English Edition).2022; 46(3): 132. CrossRef
Expression of Peripheral Blood DCs CD86, CD80, and Th1/Th2 in Sepsis Patients and Their Value on Survival Prediction
Ke Du, Shaobo Hao, Heyun Luan, Min Tang
Computational and Mathematical Methods in Medicine.2022; 2022: 1. CrossRef
Recombinant Activated Protein C (rhAPC) Affects Lipopolysaccharide-Induced Mechanical Compliance Changes and Beat Frequency of mESC-Derived Cardiomyocyte Monolayers
Aysegül Temiz Artmann, Eylem Kurulgan Demirci, Ipek Seda Fırat, Hakan Oflaz, Gerhard M. Artmann
Shock.2022; 57(4): 544. CrossRef
Acute cholecystitis associated with sepsis-induced ischemic cardiomyopathy
Ke-Shiuan Ju, Ying-Shih Su, Wen-Sen Lee
Journal of Infection.2022; 84(6): 834. CrossRef
An Overview on Mitochondrial-Based Therapies in Sepsis-Related Myocardial Dysfunction: Mitochondrial Transplantation as a Promising Approach
Behnaz Mokhtari, Rana Yavari, Reza Badalzadeh, Ata Mahmoodpoor, Jayaraman Tharmalingam
Canadian Journal of Infectious Diseases and Medical Microbiology.2022; 2022: 1. CrossRef
Pathological role of the calcium‐sensing receptor in sepsis‐induced hypotensive shock: Therapeutic possibilities and unanswered questions
Ankita Sood, Gaaminepreet Singh, Thakur G. Singh, Kirti Gupta
Drug Development Research.2022; 83(6): 1241. CrossRef
Diminazene aceturate mitigates cardiomyopathy by interfering with renin-angiotensin system in a septic rat model
Zhaoqing Lu, Di Wu, Zheng Wang, Hanyu Zhang, Yufan Du, Guoxing Wang
BMC Pharmacology and Toxicology.2022;[Epub] CrossRef
Serum Sestrin2 Was Lower in Septic Shock Patients with Cardiomyopathy
Rongjin Huang, Feng Chen, Aiying Zeng, Jun Ke, Shirong Lin, QiXing Chen
Disease Markers.2022; 2022: 1. CrossRef
Tidy up - The unfolded protein response in sepsis
Wolfgang Vivas, Sebastian Weis
Frontiers in Immunology.2022;[Epub] CrossRef
DAMPs Released from Proinflammatory Macrophages Induce Inflammation in Cardiomyocytes via Activation of TLR4 and TNFR
Carolina Neu, Yvonne Thiele, Fabienne Horr, Christian Beckers, Nadine Frank, Gernot Marx, Lukas Martin, Sandra Kraemer, Elisabeth Zechendorf
International Journal of Molecular Sciences.2022; 23(24): 15522. CrossRef
Targeting the TXNIP‐NLRP3 interaction with PSSM1443 to suppress inflammation in sepsis‐induced myocardial dysfunction
Linhua Wang, Hongsheng Zhao, Huifen Xu, Xiangxin Liu, Xinlong Chen, Qingyun Peng, Mingbing Xiao
Journal of Cellular Physiology.2021; 236(6): 4625. CrossRef
Sepsis—Pathophysiology and Therapeutic Concepts
Dominik Jarczak, Stefan Kluge, Axel Nierhaus
Frontiers in Medicine.2021;[Epub] CrossRef
Rho-Proteins and Downstream Pathways as Potential Targets in Sepsis and Septic Shock: What Have We Learned from Basic Research
Maria Luísa da Silveira Hahmeyer, José Eduardo da Silva-Santos
Cells.2021; 10(8): 1844. CrossRef
Deep-learning model for screening sepsis using electrocardiography
Joon-myoung Kwon, Ye Rang Lee, Min-Seung Jung, Yoon-Ji Lee, Yong-Yeon Jo, Da-Young Kang, Soo Youn Lee, Yong-Hyeon Cho, Jae-Hyun Shin, Jang-Hyeon Ban, Kyung-Hee Kim
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.2021;[Epub] CrossRef
Levosimendan versus dobutamine for sepsis-induced cardiac dysfunction: a systematic review and meta-analysis
Dong-Hua Liu, Yi-Le Ning, Yan-Yan Lei, Jing Chen, Yan-Yan Liu, Xin-Feng Lin, Zhong-Qi Yang, Shao-Xiang Xian, Wei-Tao Chen
Scientific Reports.2021;[Epub] CrossRef
Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1
Chun Liu, Jianhua Xue, Bo Xu, Aixian Zhang, Lili Qin, Jiajia Liu, Yang Yang, Antonio C. Campos de Carvalho
Stem Cells International.2021; 2021: 1. CrossRef

Case Report

Cardiology/Pediatric
Transfusion Associated Hyperkalemia and Cardiac Arrest in an Infant after Extracorporeal Membrane Oxygenation: Do Wan Kim, Kyeong Ryeol Cheon, Duck Cho, Kyo Seon Lee, Hwa Jin Cho, In Seok Jeong; Korean J Crit Care Med. 2015;30(2):132-134. Published online May 31, 2015; DOI: https://doi.org/10.4266/kjccm.2015.30.2.132

7,592 View
96 Download
5 Crossref

Abstract PDF

Cardiac arrest associated with hyperkalemia during red blood cell transfusion is a rare but fatal complication. Herein, we report a case of transfusion-associated cardiac arrest following the initiation of extracorporeal membrane oxygenation support in a 9-month old infant. Her serum potassium level was increased to 9.0 mEq/L, soon after the newly primed circuit with pre-stored red blood cell (RBC) was started and followed by sudden cardiac arrest. Eventually, circulation was restored and the potassium level decreased to 5.1 mEq/L after 5 min. Extracorporeal membrane oxygenation (ECMO) priming is a relatively massive transfusion into a pediatric patient. Thus, to prevent cardiac arrest during blood-primed ECMO in neonates and infants, freshly irradiated and washed RBCs should be used when priming the ECMO circuit, to minimize the potassium concentration. Also, physicians should be aware of all possible complications associated with transfusions during ECMO.

Citations

Citations to this article as recorded by

Transfusion-associated graft-versus-host disease, transfusion-associated hyperkalemia, and potassium filtration: advancing safety and sufficiency of the blood supply
Kenneth E. Nollet, Alain M. Ngoma, Hitoshi Ohto
Transfusion and Apheresis Science.2022; 61(2): 103408. CrossRef
Transfusion-Associated Hyperkalemic Cardiac Arrest in Neonatal, Infant, and Pediatric Patients
Morgan Burke, Pranava Sinha, Naomi L. C. Luban, Nikki Gillum Posnack
Frontiers in Pediatrics.2021;[Epub] CrossRef
Double-filtered leukoreduction as a method for risk reduction of transfusion-associated graft-versus-host disease
Sejong Chun, Minh-Trang Thi Phan, Saetbyul Hong, Jehoon Yang, Yeup Yoon, Sangbin Han, Jungwon Kang, Mark H. Yazer, Jaehyun Kim, Duck Cho, Senthilnathan Palaniyandi
PLOS ONE.2020; 15(3): e0229724. CrossRef
Anticoagulation Therapy during Extracorporeal Membrane Oxygenator Support in Pediatric Patients
Hwa Jin Cho, Do Wan Kim, Gwan Sic Kim, In Seok Jeong
Chonnam Medical Journal.2017; 53(2): 110. CrossRef
Blood Transfusion Strategies in Patients Supported by Extracorporeal Membrane Oxygenation
Yoon Hee Kim
The Korean Journal of Critical Care Medicine.2015; 30(3): 139. CrossRef

Original Article

Cardiology/Neurology
Efficacy of Electroencephalographic Monitoring for the Evaluation of Intracranial Injury during Extracorporeal Membrane Oxygenation Support in Neonates and Infants: In Seok Jeong, Young Jong Woo, Do Wan Kim, Nan Yeol Kim, Hwa Jin Cho, Jae Sook Ma; Korean J Crit Care Med. 2014;29(2):70-76. Published online May 31, 2014; DOI: https://doi.org/10.4266/kjccm.2014.29.2.70

4,893 View
43 Download
2 Crossref

Abstract PDF

Background
Neurological complications are a serious concern during extracorporeal membrane oxygenation (ECMO) support in neonates and infants. However, evaluating brain injury during ECMO has limitations. Herein, we report our experience with bedside electroencephalographic monitoring during ECMO support and compared this to post-ECMO brain imaging studies and immediate neurologic outcomes.
Methods
We retrospectively reviewed the data for 18 children who underwent ECMO. From these subjects, we reviewed the medical records of 10 subjects who underwent bedside EEG monitoring during ECMO support. We collected data on patient demographics, clinical details of the ECMO course, electroencephalographic monitoring, brain imaging results, and neurologic outcomes.
Results
The median age was 4 months (range: 7 days-22 months), the median weight was 5 (3.6-12) kg, and the median length of ECMO therapy was 86 (27-206) hours. Eight patients (80%) were weaned successfully, and seven (70%) survived to discharge. Those with normal to mildly abnormal electroencephalographic findings had non-specific to mildly abnormal brain computed tomography findings and no neurologic impairment. Those patients with a moderately to severely abnormal electroencephalograph had markedly abnormal brain computed tomography findings and remained neurologically impaired.
Conclusions
Normal electroencephalographic findings are closely related to normal or mild neurologic impairment. Our results indicate that electroencephalographic monitoring during ECMO support can be a feasible tool for evaluating brain injury although further prospective studies are needed.

Citations

Citations to this article as recorded by

Neurological monitoring in ECMO patients: current state of practice, challenges and lessons
Hassan Aboul-Nour, Ammar Jumah, Hafsa Abdulla, Amreeta Sharma, Bradley Howell, Namita Jayaprakash, Jayna Gardner-Gray
Acta Neurologica Belgica.2023; 123(2): 341. CrossRef
Neurological Monitoring and Complications of Pediatric Extracorporeal Membrane Oxygenation Support
Ahmed S. Said, Kristin P. Guilliams, Melania M. Bembea
Pediatric Neurology.2020; 108: 31. CrossRef

Case Report

Fatal Left Ventricular Thrombosis in an Infant Receiving Extracorporeal Membrane Oxygenation Support: A Case Report: Hwa Jin Cho, Byung Young Kim, Eun Song Song, Sang Gi Oh, Bong Suk Oh, In Seok Jeong; Korean J Crit Care Med. 2013;28(2):123-126.; DOI: https://doi.org/10.4266/kjccm.2013.28.2.123

3,066 View
16 Download
2 Crossref

Abstract PDF

Thromboembolism in patients receiving extracorporeal membrane oxygenation (ECMO) support is a feared complication. Systemic anticoagulation during ECMO in patients with a massively dilated left ventricle (LV) and decreased LV systolic function is still debated. Hearin, we report a case of a 5-month old infant on ECMO support who had fatal thrombus formation in the massively dilated LV and a consequent thromboembolic event.

Citations

Citations to this article as recorded by

Activated Partial Thromboplastin Time Versus Anti-Factor Xa Monitoring of Heparin Anticoagulation in Adult Venoarterial Extracorporeal Membrane Oxygenation Patients
Caitlin E. Kulig, Kendra J. Schomer, Hugh B. Black, William E. Dager
ASAIO Journal.2021; 67(4): 411. CrossRef
Anticoagulation Therapy during Extracorporeal Membrane Oxygenator Support in Pediatric Patients
Hwa Jin Cho, Do Wan Kim, Gwan Sic Kim, In Seok Jeong
Chonnam Medical Journal.2017; 53(2): 110. CrossRef

First
Prev
Page of 1
Next
Last

Search